is an effective approach to rapidly identify novel indications for known drugs and compounds. It is a way to bring therapeutic applications to patients at affordable costs. Oncode has acquired the next generation Drug Repurposing library, which contains more than 6.000 drugs in various stages of clinical development (abandoned, off-patent, launched, etc). The unique composition of the library is described in a publication of the Broad Institute in Nature Medicine.

are a great tool in fundamental research and have revolutionized the way cancer can be treated in the clinic. The facility uses a state-of-the-art cellular immunization method in mice which has a very high efficiency. With this method, antibodies can be raised against for instance low immunogenic membrane proteins. In addition, this facility can make antibodies against conformational epitopes and generate agonistic and antagonistic antibodies.

is a key step in understanding biological processes. The protein facility serves as a one-stop-shop for Oncode researchers looking into the functional characteristics of their proteins of interest. By facilitating the analysis of the 3D conformation of a protein and the way it interacts with other proteins, nucleic acids, lipids, carbohydrates, and small molecules provides a lot of insight in how it functions in health and disease

is a rapidly evolving field of research which opens new doors towards understanding tumor heterogeneity and therapy resistance. Oncode supported setting up UFO biosciences, a facility dedicated to isolating and profiling single cells. The team at UFO helps to get from tumor sample to novel targets with their FUNsice technology and based on the dynamic behaviour, molecular identity or imageable characteristics of your cells of interest.

from clinical studies into colorectal cancer are a rich source of data. With the help of Oncode, a comprehensive online CRC catalogue was set up. The catalogue helps to get an overview of the clinical studies that have been conducted in The Netherlands, find data and sample collections for your research, assess available data in an aggregated form and gather large datasets and conduct individual-participant data meta-analyses.

are here to stay and have many applications in oncology. From a fundamental perspective AI and DL are powerful tools in cancer genomics, proteomics, and structural cell biology. In clinical practice it can help in pathology, radiology and radiotherapy. To enable our community to reap the benefits of AI and DL, we have set up a graphical processor unit infrastructure distributed amongst three Oncode partner institutes.

Is a powerful approach to measure the full protein and/or metabolite composition of individual cells. Single cell-based data on the level of proteins can shed light on cellular heterogeneity, a hallmark of many tumors. Oncode has supported setting up the Proteomics4Oncode facility which offers mass spectrometry-based (interaction) proteomics expertise and service to help you answer your research questions.

can help to unravel underlying mechanisms of the development of tumors and the response to treatments. In recent years many novel sequencing technologies have been established. The Single-Cell Core now makes these technologies available to the Oncode community, enabling it to look into genetic variations and epigenetic features of individual cells.