Technology Roadshow

Oncode Institute aims to speed up the translation of groundbreaking fundamental research into the clinic, in order to improve the lives of cancer patients. One of the ways Oncode enables its community to do so is by investing in state-of-the-art technologies and facilities. Take a tour along the eight different facilities we have made available to our community over the past years.

Performing screens at NKI and LUMC

The Drug Repurposing program enables all Oncode researchers to have access to the library. Oncode provides interested investigators with the technical infrastructure and expertise required to perform compound screens, even with a complex experimental setup.

Monoclonal antibodies

are a great tool in fundamental research and have revolutionized the way cancer can be treated in the clinic. The facility uses a state-of-the-art cellular immunization method in mice which has a very high efficiency. With this method, antibodies can be raised against for instance low immunogenic membrane proteins. In addition, this facility can make antibodies against conformational epitopes and generate agonistic and antagonistic antibodies.

Producing antibodies at UMC Utrecht

The Oncode Therapeutic Antibody Project works together with Oncode researchers to develop new monoclonal antibodies, suited for specific fundamental research purposes or clinical applications. 

Find out more about our approach

Proteins4­Oncode at NKI 

The Protein Facility supports Oncode researchers with expressing and purifying proteins, characterizing them (quality control), and crystallizing them for X-ray analysis.

Find out more about our approach

Analyzing proteins

is a key step in understanding biological processes. The protein facility serves as a one-stop-shop for Oncode researchers looking into the functional characteristics of their proteins of interest. By facilitating the analysis of the 3D conformation of a protein and the way it interacts with other proteins, nucleic acids, lipids, carbohydrates, and small molecules provides a lot of insight in how it functions in health and disease

Analyzing single cells

is a rapidly evolving field of research which opens new doors towards understanding tumor heterogeneity and therapy resistance. Oncode supported setting up UFO biosciences, a facility dedicated to isolating and profiling single cells. The team at UFO helps to get from tumor sample to novel targets with their FUNsice technology and based on the dynamic behaviour, molecular identity or imageable characteristics of your cells of interest.

UFO Biosciences at Erasmus MC

This facility offers services to screen, identify, isolate and profile single cells to find truly meaningful genes. UFO helps to find new strategies to target exactly those cells that matter.

Find out more on site of UFO biosciences

CRC catalogue at Amsterdam UMC and UMC Utrecht

The online platform, made in collaboration with Health-RI and Molgenis, contains all available materials (tissue, blood, residual material) from clinical studies in the field of colorectal cancer that can be used for research purposes.

Find out more

Biomaterials and omics data

from clinical studies into colorectal cancer are a rich source of data. With the help of Oncode, a comprehensive online CRC catalogue was set up. The catalogue helps to get an overview of the clinical studies that have been conducted in The Netherlands, find data and sample collections for your research, assess available data in an aggregated form and gather large datasets and conduct individual-participant data meta-analyses.

Artificial Intelligence and Deep Learning

are here to stay and have many applications in oncology. From a fundamental perspective AI and DL are powerful tools in cancer genomics, proteomics, and structural cell biology. In clinical practice it can help in pathology, radiology and radiotherapy. To enable our community to reap the benefits of AI and DL, we have set up a graphical processor unit infrastructure distributed amongst three Oncode partner institutes.

Oncode GPU infrastructure

The infrastructure ensures immediate local availability to enable new science, provides a testbed for distributed computing, allows to evaluate solutions for data security/privacy and storage, ensures local extensibility, and offers the possibility to leverage local resources for Oncode use.

Find out more about this facility

Proteomics4­Oncode at UMC Utrecht

The facility operates five state-of-the-art, high-resolution mass spectrometers. These instruments can be used for a broad variety of applications, ranging from quantitative whole proteome measurements to post-translational modification (PTM) analyses. 

Find out what else the facility can do

Single cell proteomics

Is a powerful approach to measure the full protein and/or metabolite composition of individual cells. Single cell-based data on the level of proteins can shed light on cellular heterogeneity, a hallmark of many tumors. Oncode has supported setting up the Proteomics4Oncode facility which offers mass spectrometry-based (interaction) proteomics expertise and service to help you answer your research questions.

Single-cell (epi) genome sequencing

can help to unravel underlying mechanisms of the development of tumors and the response to treatments. In recent years many novel sequencing technologies have been established. The Single-Cell Core now makes these technologies available to the Oncode community, enabling it to look into genetic variations and epigenetic features of individual cells.

Single-cell Core at Hubrecht Institute

The facility supports researchers with DNA analysis at the level of individual cells, both for genomic DNA sequencing as well as epigenetic measurements. Services include whole genome sequencing, karyotyping, chromatin profiling and DNA methylation analysis.

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